Multiple Solubility Maxima of Oxolinic Acid in Mixed Solvents and a New Extension of Hildebrand Solubility Approach.
نویسندگان
چکیده
منابع مشابه
Multiple solubility maxima of oxolinic acid in mixed solvents and a new extension of Hildebrand solubility approach.
A new extension of the Hildebrand solubility approach which describes drug solubility in solvent mixtures showing multiple solubility peaks, the chameleonic effect, is proposed. The experimental solubilities of oxolinic acid were measured at 25 degrees C in solvent mixtures of ethanol-water and ethanol-ethyl acetate. A plot of the mole fraction of the drug against the solubility parameter (delt...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2000
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.48.175